C-Kit热点突变检测试剂盒简介

1、检测意义
胃肠道间质瘤（GIST）的c-kit基因突变率>85%，突变主要见于恶性GIST。c-kit突变对靶向药物尹马替尼（Imatinib）有抗药性，预后更差。

2、适用范围
筛选尹马替尼（Imatinib）适用的胃肠间质瘤患者，判断尹马替尼治疗的预后效果。检测手术或穿刺标本，也用于高灵敏度检测血清、血浆或全血等微量突变。

3、试剂盒规格
产品编号 产品名称 规格 价格
WZ-C12 C-Kit热点突变检测试剂盒 12人份 询价
WZ-C24 C-Kit热点突变检测试剂盒 24人份 询价
WZ-C48 C-Kit热点突变检测试剂盒 48人份 询价

4、参考文献
 Kiesel H, Müller AM, Schmitt-Graeff A, et al. Dramatic and durable efficacy of imatinib in an advanced angiosarcoma without detectable KIT and PDGFRA mutations. Cancer Biol Ther. 2009;8(4):319-21.
 Bachet JB, Hostein I, Le Cesne A. Prognosis and predictive value of KIT exon 11 deletion in GISTs. Br J Cancer. 2009;101(1):7-11.
 Blay JY, Reichardt P. Advanced gastrointestinal stromal tumor in Europe: a review of updated treatment recommendations. Expert Rev Anticancer Ther. 2009;9(6):831-8.
 Siehl J, Thiel E. C-kit, GIST, and imatinib. Recent Results Cancer Res. 2007;176:145-51.
 Fletcher JA, Rubin BP. KIT mutations in GIST. Curr Opin Genet Dev. 2007;17(1):3-7.