产品名：重组人Flt3-Ligand（Flt3-L）
产品号：LT0079
别名：Fms-related tyrosine kinase 3 ligand, Flt3L
产品信息：Flt3-L是调节早期造血干细胞增殖的生长因子。Flt3-L与表达酪氨酸激酶受体Flt3的细胞结合。Flt3-L本身并不能刺激早期造血干细胞的增殖，但与其他CSFs和白介素协同作用可诱导早期造血干细胞的生长和分化。与SCF不同，Flt3-L对肥大细胞没有活性。已经确定了Flt3-L的多种亚型。主要的生物活性是被固定在细胞表面作为跨膜蛋白的胞外区域(209 a.a .)。这种膜结合的亚型可以通过蛋白水解来产生，是一种具有生物活性的可溶性亚型。重组人Flt3-L是一种可溶性的17.6 kDa蛋白，由155个氨基酸残基组成。
 
英文描述：
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.
 
氨基酸序列:
TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
来源:
E.coli
保存条件：
4℃保存6个月，-20℃保存一年或者-80℃长期保存。
 
 
纯度&内毒素:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level <0.5EU/ug


The purity of rh Flt3-L  was determined by SDS-PAGE reduced rh Flt3-L and staining overnight with Coomassie Blue.