WEHI-3/WEHI-3细胞系/WEHI-3细胞株/WEHI-3小鼠血液细胞

Cell line name WEHI-3

Synonyms Wehi-3; WEHI 3; WEHI3

Accession CVCL_3622

Resource Identification Initiative To cite this cell line use: WEHI-3 (RRID:CVCL_3622)

Comments Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).

Doubling time: 18 hours (Note=In 2% FCS) (PubMed=3005406).

Transformant: DrugBank; DB11057; Mineral oil.

Omics: SNP array analysis.

Misspelling: WEIHI3; Note=Occasionally.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Disease Mouse leukemia (NCIt: C21604)

Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)

Breed/subspecies: BALB/c.

Hierarchy Children:

CVCL_0J48 (HUCL-1) CVCL_2239 (WEHI-3B)

Sex of cell Male

Age at sampling 6M

Category Cancer cell line

STR profile Source(s): PubMed=31220119

Markers:

Mouse STR 1-1 15,16,18

Mouse STR 1-2 17

Mouse STR 2-1 16

Mouse STR 3-2 14,15

Mouse STR 4-2 21.3

Mouse STR 5-5 14

Mouse STR 6-4 18,19,20,21

Mouse STR 6-7 12,13,14

Mouse STR 7-1 25.2,26.2,27.2

Mouse STR 8-1 13,14

Mouse STR 11-2 18,19

Mouse STR 12-1 16,17

Mouse STR 13-1 15.2,16.2

Mouse STR 15-3 22.3,23.3,25.5

Mouse STR 17-2 16

Mouse STR 18-3 18

Mouse STR 19-2 12,13

Mouse STR X-1 26,27

Run an STR similarity search on this cell line

Web pages Publications

PubMed=5259325; DOI=10.1093/jnci/43.4.963

Warner N.L., Moore M.A.S., Metcalf D.

A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content.

J. Natl. Cancer Inst. 43:963-982(1969)

PubMed=4543620; DOI=10.3181/00379727-144-37688

Rollinghoff M., Warner N.L.

Specificity of in vivo tumor rejection assessed by mixing immune spleen cells with target and unrelated tumor cells.

Proc. Soc. Exp. Biol. Med. 144:813-818(1973)

PubMed=6170720; DOI=10.1084/jem.154.5.1419; PMCID=PMC2186508

McKean D.J., Infante A.J., Nilson A.E., Kimoto M., Fathman C.G., Walker E.B., Warner N.L.

Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells.

J. Exp. Med. 154:1419-1431(1981)

PubMed=6687612

de Weger R.A., van Loveren H., van Basten C.D.H., Oskam R., van der Zeijst B.A.M., Den Otter W.

Functional activities of the NCTC 1469 macrophage-like cell line: comparison of the NCTC 1469 cell line with various other macrophage-like cell lines.

J. Reticuloendothel. Soc. 33:55-66(1983)

PubMed=3005406; DOI=10.4049/jimmunol.136.6.2181

Morel P.A., Manolagas S.C., Provvedini D.M., Wegmann D.R., Chiller J.M.

Interferon-gamma-induced IA expression in WEHI-3 cells is enhanced by the presence of 1,25-dihydroxyvitamin D3.

J. Immunol. 136:2181-2186(1986)

PubMed=3792703; DOI=10.1111/j.1432-0436.1986.tb00568.x

Leenen P.J.M., Jansen A.M.A.C., van Ewijk W.

Murine macrophage cell lines can be ordered in a linear differentiation sequence.

Differentiation 32:157-164(1986)

PubMed=25277546; DOI=10.1186/1471-2164-15-847; PMCID=PMC4198738

Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W., Morse H.C. 3rd, Pardo-Manuel de Villena F.

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.

BMC Genomics 15:847.1-847.11(2014)

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308

Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.

Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.

PLoS ONE 14:E0218412-E0218412(2019)