技术优势 Advantages
高稳定性膨胀水凝胶（线性变异＜5%）
High stability expanded hydrogel 
     
适用样本类型
FFPE样本、OCT样本、新鲜组织、PFA样本

应用场景 Application Scenes
器官结构异质性研究
肿瘤组织微环境研究
肿瘤疾病发生进展过程研究
疾病预后标志物研究
Heterogeneity of organ structure research
Microenvironment of tumor tissue research
Progression of tumor diseases research
Prognostic research of diseases

应用案例 Application

Hong L, Mei J, Sun X, et al. Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma[J]. Hepatology, 2025. doi.org/10.1097/HEP.0000000000001283

Zhang H, Hong L, Dong Z, et al. Spatially resolved C1QC+ macrophage CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response[J]. Cell Discovery, 2025. doi.org/10.1038/s41421-025-00811-2

参考文献 References

[1] Dong Z, Jiang W, Wu C, et al. Spatial proteomics of single cells and organelles on tissue slides using filter-aided expansion proteomics[J]. Nature Communications, 2024, 15(1): 9378.

[2] Mund A, Brunner A D, Mann M. Unbiased spatial proteomics with single-cell resolution in tissues [J]. Molecular Cell, 2022, 82(12): 2335-2349.

[3] Li L, Sun C, Sun Y, et al. Spatially resolved proteomics via tissue expansion[J]. Nature Communications, 2022, 13(1): 7242.

[4] Chen F, Tillberg P W, Boyden E S. Expansion microscopy [J]. Science, 2015, 347(6221): 543-548.