UbiQ 开发、制造和商业化基于泛素和泛素样蛋白的试剂。 借助这些试剂，我们能够加速泛素领域的基础研究和药物发现。

Ubi, manufactures and commercializes reagents based on ubiquitin and ubi proteins. With these reagents we enable and expedite fundamental research and drug discovery in the ubiquitin field.

Ubi specific HTS assay reagents and conducted DUB-inhibitor screening programs for internal development.

Ubi drug discovery programs on ubiquitin(-like) cascade inhibitors based on UbiQ’s Triple E platform. Ubi this platform, published in Nature Chemical Biology (2016), which exploits a reacting group that specifically traps the E1, E2 and E3 ubi enzymes. By adding this ‘hook’ onto ubiquitin itself or onto a small molecule, it had become possible to monitor and/or block the activity of dozens of enzymes involved in protein ubi specifically. Our first program based on our Triple E technology was conducted in Sumi, which developed mechanism-based covalent SUMOylation inhibitors, targeting non-oncogene SUMO addicted Myc, Notch1 or mutant KRAS driven cancers.

背景介绍：

Biotin-Ahx-Ub-VME (UbiQ-054) 是一种有效的、不可逆的特异性去泛素化抑制剂酶 (DUB)，1 在 N 末端用生物素标记。2 氨基己酸接头用于产生生物素和 Ub 蛋白之间的额外空间，用于有效访问生物素结合实体。

 

产品详情：

Biotin-Ahx-Ub-VME (human sequence, synthetic) 

货号/UbiQ code : UbiQ-054 

批次/Batch # : B26112012-001 

规格/Amount : 50 ug, lyophilized powder 

纯度/Purity : ≥95% by cation-chromatography and RP-HPLC 

分子量/Mol. Weight : found 8944 Da, calc 8945 Da 

保存/Storage : powder at −20°C, solution at −80°C. Please avoid multiple freeze/thaw cycles

分销/Distributor：靶点科技
 

产品文献Literature：

(1) Misaghi et al. J. Biol. Chem. 2005, 280, 1512. 

(2) de Jong et al. ChemBioChem 2012, 13, 2251.