Description

As many of the cytotoxic drugs conjugated to a monoclonal antibody to form an antibody-drug conjugate (ADC) are highly hydrophobic, this covalent chemical conjugation has been shown to exert a significant effect on ADC’s physical stability, a factor that is of crucial importance for downstream ADC development. Scientists from Creative Biolabs adopt a comprehensive set of analytical approaches to fully evaluate ADC physical stability to facilitate the design and improvement of ADCs.