Description

Creative Biolabs provides custom services for the development of antibody-drug conjugates with auristatins and auristatin derivatives. Auristatins, the most commonly used payloads, can block tubulin assembly and cause G2/M phase cell cycle arrest. They are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and can powerfully bind to tubulin, thus inhibiting polymerization mediated through binding to the vinca alkaloid binding domain, and cause cells to accumulate in metaphase arrest.