Description

Technology™ (FHAT) to produce fully human monoclonal antibodies in mice. As a leading custom service provider in human antibody production field, Creative Biolabs has in-licensed two strains of "humanized" transgenic mice (FHAT mice) and successfully demonstrated their applications in discovery and production of unique fully human antibodies against various targets. By introducing human immunoglobulin loci into the germ line of mice with inactivated mouse antibody machinery, the in-licensed mouse strains can directly generate high-affinity, fully human antibodies, which avoid the subsequent costly and tedious in vitro affinity maturation and antibody humanization process. Upon immunization, the immunoglobulin transgenes undergo V(D)J joining, random nucleotide (N region) addition, class switching, and somatic mutation to generate high affinity monoclonal antibodies.