Description

Creative Biolabs has extensive experience in generating human single domain antibodies and humanizing single domain antibodies. Single domain antibodies are antibody fragments consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With beneficial pharmacologic and pharmacokinetic properties, they are ideally suited to targeting cellular antigens for molecular imaging or therapeutic purposes. However, because of their camelid or nonhuman origin, the possible immunogenicity of Nanobodies when used in the clinic is a concern.