Grade: Research grade

Factory Location: Hangzhou,China.

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

Monthly Production Capacity: hundreds of grams

Contract Manufacturing: CRO

Packaging Information: 1g, 5g, 10g, 20g, 50g,100g

Delivery Lead Time: In stock or 2-3weeks

Sample Provided: yes

Payment Terms: bank transit

Linaclotide and its active metabolite bind and agonize guanylate cyclase-C on the luminal surface of intestinal epithelium. Intracellular and extracellular cyclic guanosine monophosphate (cGMP) concentrations are subsequently increased resulting in chloride and bicarbonate secretion into the intestinal lumen. Intestinal fluid increases and GI transit is accelerated. Increased extracellular cGMP may decrease visceral pain by reducing pain-sensing nerve activity.