Grade: Research grade

Factory Location: Hangzhou

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe, Australasia,Asia,Middle East,Africa

Monthly Production Capacity: hundreds of grams

Packaging Information: 500mg,1g, 10g,50g 100g per package with icebag

Delivery Lead Time: In stock or 2-3 weeks

Sample Provided: yes

Payment Terms: T/T

Apelin is the endogenous ligand of the transmembrane G protein-coupled receptor APJ, which is widely distributed in tissues and expressed in cardiovascular, kidney, nerve and brain systems. The Apelin/APJ system has multiple biological effects such as enhancing myocardial contractility, lowering blood pressure, promoting blood vessel growth, regulating insulin secretion, pituitary hormone release and body fluid balance. Apelin precursor peptide consists of 77 amino acid residues, which are then cleaved into fragments of different amino acid lengths, including: Apelin-12, Apelin-13, Apelin-17 and Apelin-36, etc. These peptides can be produced by peptide synthesis . Studies have shown that Apelin-17 can promote platelet aggregation and promote in vitro thrombosis, while APJ receptor blocker F13A inhibits Apelin-17-induced platelet aggregation and in vitro thrombosis. In addition, Apelin-17 has a synergistic platelet activator thrombin-induced platelet aggregation.