产品信息

别名	Interleukin-4 Receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha
物种	Cynomolgus
表达宿主	Human Cells
序列信息	Met26-Arg232
检索号	G7Q0S7
分子量	24.6 kDa
表观分子量	38-58kDa
生物活性	Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells.The ED50 for this effect is 2.38ng/ml.

产品特性

纯度	>95% as determined by reducing SDS-PAGE.
内毒素	< 1.0 EU per µg as determined by LAL test.
保存	Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输	Ambient temperature or ice pack.
制剂	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-4 Receptor subunit alpha (IL-4RA), alos known as Soluble IL-4 Receptor subunit alpha, belongs tothe type I Cytokine Receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functionsas Receptor for both Interleukin 4 and Interleukin 13 and couples to the JAK1/ 2/ 3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/ IL13 responses are involved in regulating IgEproduction and Chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin Receptor substrates, IRS1/ IRS2. The functional IL4 Receptor isformed by initial binding of IL4 to IL4R. Sub sequently it recruits to the complex of the common gammachain. In immune cells, IL-4RA creates a type I Receptor. In non-immune cells, it forms a type II Receptorwith of IL13RA1. IL4R can also interact with the IL13/ IL13RA1 complex to form a similar type II Receptor andinteracts with the SH2-containing phosphatases, PTPN6/ SHIP1, PTPN11/ SHIP2 and IN,P.P5D/ SHIP.