Grade: Pharmaceutical Grade

Factory Location: Xiamen, Fujian

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

Monthly Production Capacity: 1000kg

Packaging Information: 25kg/drum 1kg/bottle

Delivery Lead Time: 7 days after payment

Sample Provided: yes

Payment Terms: L/L

 

Product Information

 

Product name	Ademetionine 1,4-butanedisulfonate / SAM / SAMe
CAS No.	101020-79-5
Molecular Formula	C23H41N6O17S5-
Molecular Weight	833.91
Quality Standard	99% up by HPLC
Appearance	White powder

 

COA of Ademetionine 1,4-butanedisulfonate

 

ITEMS	STANDARDS	RESULTS
Appearance	A white or almost white powder	White powder
Solubility	Freely soluble in water, practically insoluble in ethanol and in acetone.	Conforms
Identification	1.    The gas it produced can make wet potassium iodate test pater show blue.	Conforms
	2.    UV: it has absorption maximum at the 258nm
	3.    HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference.
pH	2.1~2.5	2.4
Clarity and color of solution	Color: ≤Y3# or YG3#	Conforms
	A solution should be clear.
Isomers	(S,S-Isomer) ≥70%	74.00%
Related substances	Adenine≤0.4%	0.05%
	S-Adenosyl-L-Homocysteine≤0.4%	0.09%
	Methylthioadenosine≤2.0%	0.43%
	Decarboxylation adenosine methionine≤1.2%	1.00%
	The other unknown impurities≤1.0%	0.05%
	Total of impurities≤4.0%	1.80%
Water	≤6.0%	2.40%
Residual solvents	Ethyl acetate≤5000ppm	Conforms
Microbial limit tests	Bacteria≤1000cfu/g	Conforms
Bacterial endotoxins	≤0.438 EU/mg	Conforms
Content (dried basis)	Butanedisuphonic acid: 46.0~51.0%	47.20%
	Adenosine methionine: 48.0~53.0%	52.20%
	Total≥96.0%	99.40%
Conclusion	Conforms to enterprise standard

 

Usage

 

Function of Ademetionine 1,4-butanedisulfonate

Ademetionine 1,4-butanedisulfonate (SAM / SAMe) is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, coenzyme A, etc.) (transsulfation) , participates important functions of biochemical reaction in the body.

 

The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:

1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.

2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.

3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.

 

Indication of Ademetionine 1,4-butanedisulfonate:

Suitable for intrahepatic cholestasis before and after cirrhosis.

Suitable for intrahepatic cholestasis during pregnancy.