Grade: Pharmaceutical Grade

Factory Location: Xiamen, Fujian

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

Monthly Production Capacity: 1000kg

Packaging Information: 25kg/drum 1kg/bottle

Delivery Lead Time: 7 days after payment

Sample Provided: yes

Payment Terms: L/L

 

Product Information

 

Product name	Candesartan cilexetil
CAS No.	145040-37-5
Molecular Formula	C33H34N6O6
Molecular Weight	610.66
Quality Standard	99% up, Medicine Grade
Appearance	White powder

 

COA of Candesartan cilexetil

 

Items	Specifications	Results
Appearance	A white or almost white powder	White powder
Identification-IR	Complies with the reference spectrum	Complies
Identification- UV	Maximal  absorptions   at    254nm, minimum absorption at 242nm	Complies
Water	≤ 0.3%	0.19%
Residual solvents
Methanol	≤ 3000ppm	Not found
Ethanol	≤ 5000ppm	Not found
Ethyl ether	≤ 5000ppm	68ppm
Acetone	≤ 5000ppm	482ppm
Ethyl acetate	≤ 5000ppm	Not found
Dichloromethane	≤ 600ppm	Not found
Dimethylformamide	≤ 880ppm	Not found
Related substances
Impurity A	≤ 0.15%	< 0.05%
Impurity B	≤ 0.3%	< 0.05%
Impurity F	≤ 0.2%	< 0.05%
Impurity G	≤ 0.2%	< 0.05%
Impurity H	≤ 0.15%	Not found
Other individual impurity	≤ 0.10%	0.04%
Total impurities	≤ 0.6%	0.21%
Sulfated ash	≤ 0.1%	0.06%
Heavy metals	≤ 10ppm	<10ppm
Assay (Dried substance)	99.0~101.0%	99.8%
Conclusion:	The product complies with EP 9.0

 

 

Usage

 

Function of Candesartan cilexetil
Candesartan cilexetil is an angiotensin II receptor antagonist, also referred to as an ARB drug for short. Candesartan cilexetil is currently recognized as a first-line treatment for hypertension. Candesartan cilexetil tablets can bind to the AT1 receptor of vascular smooth muscle, thereby antagonizing the vasoconstriction effect of angiotensin II and reducing the resistance of peripheral blood vessels.

Among the similar ARB drugs, candesartan cilexetil has the strongest receptor affinity, so it has a longer binding time, so it is a long-acting angiotensin II receptor antagonist, which can be administered once every 24 hours. Can play a stable, long-lasting and effective antihypertensive effect. Not only that, studies have found that candesartan cilexetil can also improve fibrinolytic activity, promote the recovery of vascular endothelial function, and help protect cardiovascular and cerebrovascular other than blood pressure.