Grade: Pharmaceutical Grade

Factory Location: Xiamen, Fujian

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

Monthly Production Capacity: 1000kg

Packaging Information: 25kg/drum 1kg/bottle

Delivery Lead Time: 7 days after payment

Sample Provided: yes

Payment Terms: L/L

 

Product Information

 

Product name	Donepezil
CAS No.	120014-06-4
Molecular Formula	C24H29NO3
Molecular Weight	379.49
Quality Standard	99% up by HPLC
Appearance	White powder

 

COA of Donepezil

 

ITEMS	SPECIFICATIONS	RESULTS
APPEARANCE	WHITE OR ALMOST WHITE CRYSTALLINE POWDER	CONFORMS
SOLUBILITY	TO MATCH WORKING STANDARD	CONFORMS
IDENTIFICATION	1)     BY UV ABSORPTION,TO MATCH WORKING STANDARD 2)     BY IR ABSORPTION,TO MATCH WORKING STANDARD	CONFORMS   CONFORMS
MELTING POINT	86-90℃	87.5-88.5℃
RELATED SUBSTANCE
TOTAL	≤1.0%	0.14%
SINGLE IMPURITY (UNKNOWN)	≤0.80%	<0.8%
LOSS ON DRYING	≤1.0%	0.3%
RESIDUE ON IGNITION	≤0.10%	0.02%
HEAVY METAL	≤10 PPM	<10 PPM
ASSAY	≥99.0%	99.87%
CONCLUSION	CONFORMS TO THE ENTERPRISE STANDARD

 

Usage

 

Function of Donepezil
 

Donepezil is a potent, reversible, specific and noncompetitive acetylcholinesterase (AChE) inhibitor for the treatment of mild to moderate dementia.

 

In vitro studies:

Donepezil has a reversible and non-competitive inhibitory effect on AChE. It is 500-1000-fold more selective for AChE than for BuChE. Short- and long-term drug exposure to human SH-SY5Y neuroblastoma cells induces a concentration-dependent inhibition of cell proliferation independent of muscarinic or nicotinic receptor blockade and apoptosis. Donepezil reduces the number of cells in the S-G2/M phase of the cell cycle, increases the number in the G0/G1 phase, and reduces the expression of two cyclins in the G1/S and G2/M transitions: cyclinE and cyclinB. At the same time, it also increased the expression of the cell cycle repressor p21. In addition, donepezil increases action potential-dependent dopamine release and modulates nicotinic receptors in substantia nigra dopaminergic neurons.

In vivo studies:

Donepezil absorbs Chemicalbook slowly from the gastrointestinal tract in vivo, with a terminal half-life of 50-70 hours in young volunteers and more than 100 hours in elderly. After extensive hepatic metabolism, the parent compound is 93% bound to plasma proteins. Donepezil is metabolized in the liver by the cytochrome P450 system (CYP1A2-, CYP2D6-, CYP3A4-related enzymes). In animals, donepezil was unchanged in the brain and no metabolites were found in neural tissue. In plasma, urine and bile, most donepezil metabolites are O-glucuronides. After oral ingestion, peak plasma concentrations are reached within 3-5 hours, and its absorption is not affected by food. Donepezil has linear pharmacokinetics in the concentration range of 1-10 mg/day. 96% of circulating donepezil is protein bound.