98% up by HPLC Alogliptin Benzoate 850649-62-6 | Pharmaceutical Materials

Product Catagories

Medical Raw Materials

首页 > Pharmaceutical Materials > 98% up by HPLC Alogliptin Benzoate 850649-62-6

98% up by HPLC Alogliptin Benzoate 850649-62-6

单价	面议对比
询价	暂无
发货	全国
过期	长期有效
更新	2025-08-14 05:39

详细信息

Grade: Pharmaceutical Grade

Factory Location: Xiamen, China

Main Sales Markets: North America

Sample Provided: no

Payment Terms: L/C

Product name	Alogliptin benzoate
CAS No.	850649-62-6
Molecular Formula	C18H21N5O2.C7H6O2
Molecular Weight	461.52
Quality Standard	98% up by HPLC
Appearance	White powder

COA of Alogliptin benzoate

ITEMS	SPECIFICATION	RESULT
Appearance	White or off-white crystalline powder	Complies
Melting point	181.0°C ~185.0°C	182-184°C, melting and decomposition
Specific rotation	+13° ~ +18°	+14.6°
Identification	1. UV: maximum absorption at the wavelength of 278+2nm	Complies
	2. IR: be consistent with standard	Complies
	3. HPLC： the retention time of the main peak of the solution should be consistent with the retention time of the main peak of the reference solution.	Complies
Water	≤ 0.5%	0.15%
Residue on ignition	≤ 0.2%	0.09%
Heavy metals	≤ 20 ppm	Complies
Enantiomer	≤ 0.5%	ND
Residual solvents	Ethanol ≤ 5000ppm	985 ppm
	DMF ≤ 880 ppm	ND
	DCM ≤ 600 ppm	ND
	TOL ≤ 890 ppm	ND
	IPA ≤ 5000 ppm	ND
Related substances	Single impurity ≤ 0.1%	0.01%
Related substances	Total impurities≤ 2.0%	0.05%
Assay	98.0% - 102.0%	100.01%
Conclusion	The sample complies with the above specification

Usage

Alogliptin benzoate is a selective inhibitor of dipeptidyl peptidase-4 (DPP-4). Eating stimulates the small intestine to secrete elevated concentrations of incretins, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), into the bloodstream. These hormones cause islet beta cells to release insulin in a glucose-dependent manner, but these hormones are inactivated by the DPP-4 enzyme within minutes. Inhibition of DPP-4 activity by alogliptin slows the inactivation of these incretins, thereby increasing blood concentrations of these hormones and reducing fasting and postprandial blood glucose in a glucose-dependent manner in patients with type II diabetes.

Product name

Alogliptin benzoate

CAS No.

850649-62-6

Molecular Formula

C18H21N5O2.C7H6O2

Molecular Weight

461.52

Quality Standard

98% up by HPLC

Appearance

White powder

COA of Alogliptin benzoate

ITEMS

SPECIFICATION

RESULT

Appearance

White or off-white crystalline powder

Complies

Melting point

181.0°C ~185.0°C

182-184°C, melting and decomposition

Specific rotation

+13° ~ +18°

+14.6°

Identification

1. UV: maximum absorption at the wavelength of 278+2nm

Complies

2. IR: be consistent with standard

Complies

3. HPLC： the retention time of the main peak of the solution should be consistent with the retention time of the main peak of the reference solution.

Complies

Water

≤ 0.5%

0.15%

Residue on ignition

≤ 0.2%

0.09%

Heavy metals

≤ 20 ppm

Complies

Enantiomer

≤ 0.5%

ND

Residual solvents

Ethanol ≤ 5000ppm

985 ppm

DMF ≤ 880 ppm

ND

DCM ≤ 600 ppm

ND

TOL ≤ 890 ppm

ND

IPA ≤ 5000 ppm

ND

Related

substances

Single impurity ≤ 0.1%

0.01%

Total impurities≤ 2.0%

0.05%

Assay

98.0% - 102.0%

100.01%

Conclusion

The sample complies with the above specification

Usage