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Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
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Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
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PubMed=10737795; DOI=10.1073/pnas.97.7.3352
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APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)