Sigma货号I6657-100mg现货Itraconazole依曲康唑13611631389上海睿安生物

伊曲康唑，≥98%(HPLC)

别名:R51211，奥立康唑，孢粉

质量水平:200

测定:≥98%(TLC)

颜色:white

溶解性:chloroform:50mg/ml，clear，colorless

抗生素抗菌谱:fungi

作用机制:enzyme | inhibits

储存温度:2-8°C

应用:伊曲康唑是一种三唑类抗真菌药。用于抑制细胞色素P-450依赖性酶和麦角固醇合成。已用于抗组织胞浆菌病、芽生菌病、隐球菌脑膜炎和曲霉病。其不同的制剂用于研究小鼠侵袭性感染中的念珠菌菌株。它已被用于研究四氧嘧啶诱导的糖尿病的大鼠前胃粘膜的增殖变化。

包装:100mg in poly bottle.

生化/生理作用:伊曲康唑抑制细胞色素P-450依赖性酶，从而抑制麦角固醇的合成。它通过与14-α脱甲基酶相互作用来实现该抑制作用，14-α脱甲基酶是将羊毛甾醇转化为麦角固醇所必需的细胞色素P-450酶。麦角固醇是真菌细胞膜的重要组成部分。因此，它的抑制作用导致细胞通透性增加，造成细胞内容物外泄。伊曲康唑还可能抑制内源性呼吸、与膜磷脂相互作用、抑制酵母转化为菌丝体形式、抑制嘌呤摄取，并减少甘油三酸酯和磷脂的生物合成。

 

说明

生化/生理作用

伊曲康唑抑制细胞色素P-450依赖性酶，从而抑制麦角固醇的合成。它通过与 14-α 脱甲基酶相互作用来实现该抑制作用，14-α 脱甲基酶是将羊毛甾醇转化为麦角固醇所必需的细胞色素P-450酶。麦角固醇是真菌细胞膜的重要组成部分。因此，它的抑制作用导致细胞通透性增加，造成细胞内容物外泄。伊曲康唑还可能抑制内源性呼吸、与膜磷脂相互作用、抑制酵母转化为菌丝体形式、抑制嘌呤摄取，并减少甘油三酸酯和磷脂的生物合成。合成广谱三唑类抗真菌药。作用方式：抑制细胞色素 P450 依赖性酶，包括 14α-脱甲基酶。抑制作用导致麦角固醇（一种重要的真菌细胞壁成分）的生物合成受到阻止。

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