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Posaconazole泊沙康唑Sigma货号32103-25mg现货13611631389上海睿安生物
说明
一般描述
泊沙康唑(posaconazole)是唑类抗真菌药，最常用于治疗接合菌感染。
应用:有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。
泊沙康唑也可作为HPLC分析的参考标准品，定量分析人血浆来源的泊沙康唑。 
同行评审论文(部分文献)
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.Michael N Trinh et al.Proceedings of the National Academy of Sciences of the United States of America, 114(1), 89-94 (2016-12-21)Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug [Xu etClinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.Sophida Boonsathorn et al.Clinical pharmacokinetics, 58(1), 53-61 (2018-04-22)The objectives of this study were to investigate the population pharmacokinetics of posaconazole in immunocompromised children, evaluate the influence of patient characteristics on posaconazole exposure and perform simulations to recommend optimal starting doses. Posaconazole plasma concentrations from paediatric patients undergoingPosaconazole as salvage therapy for zygomycosis.Greenberg, R. N., et al.Antimicrobial Agents and Chemotherapy, 50.1, 126-133 (2006)Shu-Ying Yu et al.Infection and drug resistance, 11, 1537-1547 (2018-10-06)Trichosporon dohaense is a rare fungal species that has not been described in human invasive infections. In this study, we investigated two T. dohaense isolates from patients with invasive infections in two hospitals in China, as part of the ChinaCtt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae.Dorival Martins et al.Scientific reports, 9(1), 9185-9185 (2019-06-27)Fungi respond to antifungal drugs by increasing their antioxidant stress response. How this impacts antifungal efficacy remains controversial and not well understood. Here we examine the role of catalase activity in the resistance of Saccharomyces cerevisiae to the common antifungals
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