Supplied as a 0.2 μm filtered solution of 20mM PB，150mM NaCl,pH7.4.
纯度
≥95% as determined by reducing SDS-PAGE.
储存条件
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输条件
干冰运输
背景说明
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow.Endoglin as major glycoprotein of vascular endothelium，it has been found on endothelial cells，activated macrophages，fibroblasts，and smooth muscle cells.Furthermore，Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2.It may have an important role in the binding of endothelial cells to integrins and/or other RGD receptors.Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1)，which is an autosomal dominant multisystemic vascular dysplasia，characterized by recurrent epistaxis，muco-cutaneous telangiectases，gastro-intestinal hemorrhage，and pulmonary (PAVM)，cerebral (CAVM) and hepatic arteriovenous malformations.
来源
E.coli
内毒素
Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
Language
P01253 Recombinant Human CD105