Autophagy protein 5;APG5-like;Apoptosis-specific protein;APG5L;ASP;ATG5;
外观(性状)
Supplied as a 0.2 μm filtered solution of 20mM Tris,0.2M NaCl,1mM DTT,40%glycerol, pH 8.0 .
纯度
≥95% as determined by reducing SDS-PAGE.
储存条件
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输条件
干冰运输
背景说明
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy.Its expression is a relatively late event in the apoptotic process，occurring downstream of caspase activity，dramatically highly expressed in apoptotic cells.It is activated by ATG7，conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome.The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed.ATG5 plays an important role in the apoptotic process，possibly within the modified cytoskeleton.
来源
E.coli
内毒素
Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.
Language
P01252 Recombinant Human ATG5/