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是广谱的抗病毒化合物，能通过阻断病毒与宿主细胞的融合抑制包装病毒进入细胞。对多种包膜和非包膜病毒均有活性。可被用作抗流感病毒的相关研究。据报道，也是一种有效的 SARS-CoV-2 体外抑制剂。
| 基本信息 | |
| CAS | No.131707-23-8 |
| 中文名称 | 盐酸阿比朵尔 |
| 英文名称 | Arbidol Hydrochloride |
| 别名 | 盐酸阿比多尔;盐酸阿比朵尔; |
| 分子式 | C22H25BrN2O3S·HCl |
| 分子量 | 513.88 |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 680-680-9 |
| MDL | MFCD00344795 |
| SMILES | Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=C1C(CN(C)C)=C(O)C(Br)=C2 |
| InChIKey | OMZHXQXQJGCSKN-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H |
| PubChem CID | 9958103 |
| 靶点 | Influenza Virus |
| 通路 | Anti-infection |
| 背景说明 | 是广谱的抗病毒化合物,能通过阻断病毒与宿主细胞的融合抑制包装病毒进入细胞。 |
| 生物活性 | Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2].Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3]. |
| In Vitro | Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A，B and C viruses，respiratory syncytial virus，adenovirus，parainfluenza type 5 and rhinovirus type 14，avian coronavirus，infectious bronchitis virus and Marek disease virus，hepatitis B virus and hepatitis C virus[1]. |
| 细胞实验 | Umifenovir(45-180 mg/kg; p.o.; daily for 5 days)suppresses the transcription of influenza viruses(IFV)-associated inflammatory cytokines[2]. |
| 数据来源文献 | [1]. Boriskin YS， et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005. [2]. Liu Q， et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083. [3]. Wang X， et al. The anti-influenza virus drug， arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2. |
| 单位 | 瓶 |