Language
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.189388-22-5 |
| 单字母序列 | YPWF-NH2 |
| 三字母序列 | Tyr-Pro-Trp-Phe-NH2 |
| 别名 | 内MOP肽 1;EndoMor-phin 1 |
| 分子式 | C34H38N6O5 |
| 分子量 | 610.71 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 溶解性 | DMSO：≥ 50 mg/mL; *超声助溶; |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | opium肽(Opioid Peptides) |
| 规格 | EndoMor-phin 1，一种高度选择性的高亲和力μ-opioid受体激动剂 ， 对kappa3结合位点具有高亲和力 ，Ki为 20 到 30 nM 之间。EndoMor-phin 1, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. |
| In Vitro | EndoMor-phin 1 inhibits Forskolin (HY-15371) (1 μM) stimulated cyclic AMP formation with a pIC50 value of 8.03 in In CHOμ cells. EndoMor-phin 1 (1-10 μM) increases interleukin-8 secretion in Caco-2 cells. EndoMor-phin 1 (1 μM) inhibits excitatory transmission in adult rat substantia gelatinosa neurons. |
| In Vivo | EndoMor-phin 1 (i.c.v.) shows antinociceptive properties in mice, with an ED50 value of 6.16 nM. EndoMor-phin 1 (50 μg/kg, i.v.) alleviates myocardial ischemia/reperfusion injury (MIRI) by inhibiting the inflammatory response. |
| 单位 | 瓶 |
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