Human Tau pT181 Protein

Cat.#：TD-P10104

Size：                                            50ug
Protein Name：                     TAU pT181 
Synonym：                                 DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU
Uniprot No.：                            P10636-8
Expression System：              E. Coli
Compound Identity：             6xHis at C-terminus
Full Length or Truncated：Full length
Molecular Weight：            48.3 kDa
Modification                        Phosphorylation
Form：                                freeze-dried powder
Storage：                             2 days when stored at 2 to 8 °C after thawing
                                             Up to 12 months when aliquoted and stored at -20 to -80 °C 
Stability：                            ≤6 months
Purity：                                ≥80% estimated by SDS-PAGE
Supplied in：                        0.15 M Phosphate buffered saline, pH 7.4
 

Background

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimers disease, frontotemporal dementia, and other tauopathies.