Grade: Pharmaceutical Grade

Factory Location: Shandong China

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Middle East,Africa

Contract Manufacturing: CMO

Packaging Information: 5g;10g;100g

Sample Provided: yes

Payment Terms: L/C

Product Details
Product name: RESMETIROM MGL-3196

English alias:

Resmetirom; MGL-3196; 920509-32-6; VIA-3196; 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3 ,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile; MGL 3196; Resmetirom [USAN]; MGL3196; RE0V0T1ES0

CAS No. 920509-32-6

Molecular Formula: C17H12Cl2N6O4

Molecular weight: 435.22

EINECS number:

Density: 1.65±0.1g/cm3(Predicted)

Storage condition: Inertatmosphere,Storeinfreezer,under-20°C

Solubility: DMSO: 59.0 (maximum concentration mg/mL); 135.56 (maximum concentration mM)

Form: Crystalline solid

Acidity coefficient: (pKa)3.96±0.40(Predicted)

Characteristics: light yellow solid powder

Product Use: BioactivityResmetirom (MGL-3196,VIA-3196) is a hepatic-directed, orally active, selective thyroidhormonereceptorβ(THR-β) agonist with an EC50 of 0.21 μM and a 28-fold selectivity for THR-β over THR-α.

MGL-3196 has been tested for the treatment of non-alcoholic steatohepatitis and heterozygous familial hypercholesterolemia.

Product specification: 1kg/barrel, 2kg/barrel, 5kg/barrel, 10kg/barrel, 15kg/barrel, 20kg/barrel, 25kg/barrel, etc., and can be separately subcontracted according to customers' requirements.

Price: Price is for reference only, call us for one-to-one quotation.

 

MGL-3196 Upstream and downstream product information
Upstream products: 4-(Propan-2-yl)pyridazine-3,6-diol

3,6-dichloro-4-isopropylpyridazine; 3,6-dichloro-4-isopropylpyridazine

 6-(4-Amino-2,6-dichlorophenoxy)-4-isopropylpyridazin-3(2H)-one

 

 

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