重组人白介素11，Recombinant Human IL-11
货号：200-11-10UG

IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts.  It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system.  IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells.  It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury.  Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.

Source: E.coli

 

 

Synonyms: Interleukin-11, AGIF (Adipogenesis inhibitory factor)

 

 

AA Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

 

 

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

 

 

Biological Activity: The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.

 

Calculated Molecular Weight: 19.3 kDa

 

 

Accession Number: P20809

 

 

Gene ID: 3589

 

 

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)