XAV939,CHIR99021,PD0325901

M.Wt: 312.31 Formula: C14H11F3N2OS Solubility: DMSO Purity: >99% XAV939 is a cell-permeable small molecule inhibitor of the Wnt / β-catenin pathway that inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation. Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state. Wnt proteins act on a variety of stem cells that include neural, mammary and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line.