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Grade: Pharmaceutical Grade
Factory Location: anji Huzhou city china
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Asia
Monthly Production Capacity: 100gm
Packaging Information: 200mg/500mg/1g/10g/50g/100mg per package
Delivery Lead Time: 7 days after order confirmed
Sample Provided: yes
Payment Terms: T/T
Factory Supply 99% Synthetic Liraglutide Powder Peptide API CAS NO 204656-20-2
Introduction:
Liraglutide is a long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis.
Liraglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to liraglutide therapy.
Liraglutide is a lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a glucagon-like peptide-1 receptor agonist and a neuroprotective agent. It is a lipopeptide and a polypeptide.
Fuction &Application:
Liraglutide has the following pharmacological effects:
Protective effect on islet β cells
The effect of reducing body mass
Cardiovascular effects of liraglutide
Protective effect on the liver
Therapeutic effect on Alzheimer's disease (AD)
As a novel long-acting glP-1 analogue, liraglutide has 97% sequence homology with human GLP-1, which can bind and activate the GLP-1 receptor. Glp-1 receptor is the target of natural GLP-1, an endogenous intestinal Chemicalbook insulin stimulating hormone, which promotes the proliferation and differentiation of islet β cells, and significantly protects and improves the function of islet β cells. At the same time, liraglutide is simple and convenient to use, can provide 24h blood glucose control once a day, and the risk of hypoglycemia is small, and is expected to become a new drug for the treatment of type 2 diabetes.
Certificate of Analysis
|
Product Name |
Liraglutide |
Batch No. |
210201 |
|
Mfg. Date |
Feb 22, 2021 |
Exp. Date |
Feb 21, 2023 |
|
Sequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(palm-gama-Glu)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
molecular formula：C172H265N43O51， molecular weight：3751.202 |
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Test |
Specification |
Results |
|
Appearance |
White powder |
Conforms |
|
Solubility |
Soluble in water |
Conforms |
|
Purity (HPLC) |
NLT 98.0% |
99.5% |
|
Acetic Acid |
NMT 8% |
0.4% |
|
Mass spectrum |
3751.3±1.0 | 3751.8 |
|
Peptide content (N%) |
NLT80% |
94.8% |
|
Wate Content (Karl Fischer） |
NMT7.0% |
3.8% |
Storage:In an air tight container,protected from light at temperature2-8℃. Conclusion:the product complies with enterprise standard.
Not for human use without further processing.
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