Language
Grade: Pharmaceutical Grade
Factory Location: Shandong
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Monthly Production Capacity: 100kg
Contract Manufacturing: CRO,CMO
Packaging Information: 1KG/BAG
Delivery Lead Time: 15days
Sample Provided: yes
Payment Terms: L/C
Product Description
Product name Lacosamide
Synonyms (R)-2-Acetamido-N-benzyl-3-methoxypropanamide
CAS 175481-36-4
Molecular Formula C13H18N2O3
Molecular Weight 250.29
Product Feature
Apperance White or off white crystalline powder
Identification IR; HPLC
Melting point 140－145℃
Specific rotation +14º－+17º
Water (KF) NMT 0.5%
Residue on ignition NMT 0.3%
Heavy metals NMT 30PPM
Max single impurity: NMT 0.5%
Total impurity: NMT 1.0%
S -isomer NMT 1.0%
Assay (HPLC ) 98.0－102.0%
Lacosamide is a functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.
