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Toyopearl 和 TSKgel尺寸排阻（或分子筛）填料具有多种孔径和粒径供选择。除一些特殊应用以及用于脱盐外，分子筛填料一般不用于工业塑模制备的层析工艺。分子筛填料的机制只是根据样品中不同组分的分子大小实现先后排阻，而非利用吸附解吸附（洗脱）原理，因此大大限制了填料的载量，这就使得分子筛填料在工业生产中的应用并不广泛。
然而，充分掌握分子筛填料的孔径、粒径及其物理性质至关重要，因为分子筛填料往往是离子交换填料、疏水填料和亲和填料的最基本的骨架填料。
TOYOPEARL HW products are hydroxylated methacrylic polymer resins. TOYOPEARL HW beads are made commercially in many different pore sizes and particle diameters (30 micron and larger).
They vary from TSKgel PW beads by having a lower degree of crosslinking. Lower crosslinking makes available a larger number of resin sites for ligand immobilization when producing TOYOPEARL HW based ion exchange and hydrophobic interaction chromatography resins.
Therefore a functionalized TOYOPEARL HW resin will have a higher dynamic binding capacity than the corresponding TSKgel PW material.
Because similarly functionalized HW and PW resin types have the same backbone polymer chemistry, the selectivity for proteins and impurities remains the same.
TOYOPEARL HW based resin products can be used at high linear velocities and withstand operating pressures up to 3 bar.
