IWP-4

Product Description

IWP-4 is an inhibitor of the Wnt pathway, specifically targeting membrane-bound O-acyltransferase porcupine (PORCN) with an IC₅₀ of 25 nM. IWP-4 has been an effective component within differentiation protocols of pluripotent stem cells (PSCs) into functional cardiomyocytes when combined with CHIR99021 (Cat. No. SM-0001-0010), IWP-2 (Cat. No. SM-0003-0010), Activin A, bFGF, and BMP4 (Lian, et al.), as well as in suspension cultures for cardiac differentiation from human PSCs (Chen, et al.). IWP-4 precisely induces expression of myosin light chain in both atrial and ventricular forms for the creation of primitive cardiomyocytes from human embryonic stem cells (ESCs) (Hudson, et al.). 
 

Product Synonyms:

IWP 4, Inhibitor of WNT Production-4

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

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