CHIR99021

Product Description

Highly potent inhibitor of GSK3α and GSK3β.

CHIR99021 is a highly-potent and -selective inhibitor of GSK3α (IC₅₀ of 10) and GSK3β (IC₅₀ of 6.7), exhibiting over 500-fold selectivity when compared to its nearest homologs. CHIR99021 has been an effective component within differentiation protocols of pluripotent stem cells (PSCs) into human pancreatic beta cells (Pagliuca, et al.), neural progenitor cells (Li, et al. & Qi, et al.), cardiovascular progenitor cells (Cao, et al.), and functional cardiomyocytes (Lian, et al. & Burridge, et al.). Additionally, CHIR99021 has been shown to promote the induction of human PSCs (Li, W. et al.) and self-renewal of PSCS for maintenance purposes (Ying, et al.). 

Product Synonyms:

CT 99021, CHIR-99021, CHIR 99021
Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

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