VISQUE InVivo Smart-LF紧凑型小动物活体实时成像系统是由全球领先的科研级CCD生产商——vieworks.lnc公司设计并生产的第三代智能型小动物实时活体成像系统。该系统秉承了VISQUE系列活体成像一贯的高分辨率,智能实时,高采集速度的强大优势,同时通过增强相机性能,大大增加了信号采集的灵敏度,使得VISQUE InVivo Smart-LF紧凑型小动物活体实时成像在弱光信号成像的领域表现出色,受到了广大客户群体的一致认可,可广泛应用于各种需要荧光或者生物发光功能进行的活体内示踪研究等。
产品主要特点:
1. 高灵敏度、分辨率CCD
VISQUE InVivo Smart-LF紧凑型小动物活体实时成像系统采用了专为高端科研应用设计的,全新的制冷型科研级CCD,最小像素分辨率可达6.5μm*6.5μm,其高灵敏度的传感器可使其量子效率最大达到94%。同时该相机具有超快的,高达37fps的采集速度,优越的成像质量可保证我们的设备在快速实时动态采集过程中保持均一质量的成像结果。
2. 专业的动力学分析软件
VISQUE InVivo Smart-LF紧凑型小动物活体实时成像系统具备专业的软件开发团队,为VISQUE系列每个型号的小动物活体成像系统专业设计了强大的智能化的控制设备成像操作和数据分析的软件——Clevue软件系统。该软件可进行快速便捷的数据分析,具备一键分析功能(一键自动显示显示荧光强度水平和成像时的参数设置信息),ROI一键自动圈选,自发荧光扣除功能,多光谱融合功能,以及可以生成同时展示设置信息,原始图像,ROI信息,Bar条范围等全部信息的报告模式。图像和数值结果可直接输出为tiff,bmp,jpg,png,pdf等格式的图片或者CSV格式的数据,实时成像采集的结果可直接输出为AVI格式视频。同时该软件具备了强大的动力学分析程序,最多可对实时成像的结果进行10种的动力学分析算法。
3. 紧凑型设计
VISQUE InVivo Smart-LF紧凑型小动物活体实时成像系统采用了用户友好型设计理念,紧凑型的设计,整套设备不超过22kg,轻巧的体型方便用户在实验室的任何位置使用和挪动设备,可选配的可抽拉式加热操作台,多通道的气体麻醉机适配口,便捷的脚踏开关大大方便了用户的实验操作,为活体成像实验保驾护航。
经典实验应用:
VISQUE InVivo Smart-LF紧凑型小动物活体实时成像系统可广泛应用于,但不仅限于以下荧光和生物发光成像实验中。
1. 使用生物发光成像功能追踪肿瘤转移过程;
2. 使用荧光或生物发光对实体肿瘤进行成像;
3. 评估脑血流,下肢血流,淋巴管等的结构和功能;
4. 新药或者药物递送系统的药代动力学研究;
5. 评估新药或者肿瘤治疗方案在关节炎,动脉粥样硬化,自身免疫性疾病,血管生成等作用中的疗效。
部分引用文献:
一、2020年:
- Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Labeling and Tracking T Cells Via Dual-Modal Computed Tomography and Fluorescence Imaging,Biomacromolecules,2020;
- Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy,Pharmaceutics,2020;
- Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy,Journal of Controlled Release,2020;
- Penta-fluorophenol: A Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma,Chemical Science,2020;
- Heme Oxygenase 1‐Targeted Hybrid Nanoparticle for Chemo‐ and Immuno‐Combination Therapy in Acute Myelogenous Leukemia,Advanced Science,2020;
- Detecting Cysteine in Bioimaging with a Near‐Infrared Probe Based on a Novel Fluorescence Quenching Mechanism,ChemBioChem,2020;
- Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy,Journal of Medicinal Chemistry,2020;
- In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a β-Galactosidase-Activatable Nanoprobe,Analytical Chemistry,2020;
- Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer’s disease,Biomaterials,2020;
- Precisely Traceable Drug Delivery of Azoreductase-Responsive Prodrug for Colon Targeting via Multimodal Imaging,Analytical Chemistry,2020;
- Interrogation of Folic Acid-Functionalized Nanomedicines The Regulatory Roles of Plasma Proteins Reexamined,ACS Nano,2020;
- Near-infrared probe based on novel fluorescence quenching mechanism for detection of cysteine in bioimaging,ChemBioChem,2020;
- A nanoscale photothermal agent based on a metal-organic coordination polymer as a drug-loading framework for effective combination therapy,Acta Biomaterialia,2019;
- Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells,Journal of Industrial and Engineering Chemistry,2019;
- Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance,Genome Research,2019;
- Osteogenesis and angiogenesis are simultaneously enhanced in BMP2-/VEGF-transfected adipose stem cells through activation of the YAP/TAZ signaling pathway.,Biomaterials Science,2019;
- Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-Mediated Photothermal Synergistic Immunotherapy,Nano Letters,2019;
- CXCR4-Receptor Targeted Liposomes for the Treatment of Peritoneal Fibrosis,Molecular Pharmaceutics,2019;
- pH-Switchable Coordinative Micelles for Enhancing Cellular Transfection of Biocompatible Polycations,ACS Applied Materials & Interfaces,2019;
- Silicene: Wet-Chemical Exfoliation Synthesis and Biodegradable Tumor Nanomedicine,Advanced Materials,2019;
- Self-Propelled Gemini-like LMWH-Scaffold Nanodrugs for Overall Tumor Microenvironment Manipulation via Macrophage Reprogramming and Vessel Normalization,Nano Letters,2019;
三、2018年:
1. Blood flow characteristics of diabetic patients with complications detected by optical measurements,BioMedical Engineering OnLine,2019;
2. 薄荷脑鼻用原位凝胶流变与凝胶特性研究,海军医学杂志,2019;
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