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Product Information
| Product Name | Cat# | Size | Price（¥） |
| Recombinant Equine Interleukin-2 Cys141Ser ( Equine IL-2 Cys141Ser) | 90186ES10 | 10 μg | 1,855 |
| 90186ES60 | 100 μg | 12,045 | |
| 90186ES76 | 500 μg | 26,545 |
Product Description
Interleukin 2 was initially identified as a T cell growth factor that is produced by T cells following activation by mitogens or antigens. IL-2 has since been found to also stimulate the growth and differentiation of B cells, natural killer (NK) cells, lymphocyte activated killer (LAK) cells, monocytes/macrophages and oligodendrocytes.The biological activity of IL-2 is mediated by the binding of IL-2 to cell surface receptor complexes. The functional high-affinity receptor that mediate IL‑2 signals is composed of three polypeptide chains, the IL-2 receptor alpha, beta and gamma subunits. IL-2 also signals via the intermediate affinity receptor complex of the beta and gamma subunits. In T cells, the beta and gamma subunits are shared with the IL-15 receptor complex. The gamma subunit of the IL-2 receptor complex has also been shown to be a subunit of the receptor complexes of IL-4, IL-7, IL-9 and IL-21.
Product Properties
| Synonyms | T cell growth factor; T-cell growth factor; TCGF |
| Accession | P37997 |
| GeneID | 100034204 |
| Source | E.coli-derived Equine IL-2 Cys141Ser, Ala21-Thr149(C121S). |
| Molecular Weight | Approximately 14.9 kDa. |
| AA Sequence | APTSSSKRET QQQLKQLQMD LKLLLEGVNN NKNPKLSKML TFKINMPKKA TELKHLQCLE EELKPLEEML KNFLSKDIKE LMSNINVTVL GLKGSETRFT CEYDDETGTI VEFLNKWITF SQSIFSTMT |
| Tag | None |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Purity | > 97% by SDS-PAGE and HPLC analyses. |
| Biological Activity | The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 1.0 μg/mL, corresponding to a specific activity of > 1000 IU/mg. Fully biologically active when compared to standard. |
| Endotoxin | < 0.1 EU per 1μg of the protein by the LAL method. |
| Formulation | Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 6.5. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions. |
Shipping and Storage
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only!
HB220425
