Language
| 产品分类 | Overexpression Stable Cell Line |
|---|---|
| 背景 | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| 描述 | Monoclonal Cell Line Derived from 293T Cells, Engineered for Stable Expression of canine PDL1 Using Lentiviral Technology |
| 培养基 | DMEM+10% FBS+1% P.S+Gln+2 ug/mL Puromycin |
| 宿主细胞 | 293T |
| 保存及运输 | Cells are shipped using dry ice and require liquid nitrogen storage for long term preservation. |
| 建议对照 | SKU: PME-D100009 |
| 别名 | B7-H, B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 |
| 声明 | 1. Please inspect cells upon receipt and report any issues promptly. 2. We offer one-time replacements for issues reported within a week of receipt. 3. User-induced issues are not eligible for free replacements. 4. We do not accept liability for damages resulting from cell use, storage, or loss. 5. Feedback received more than one month after receipt will not be processed. |
| 应用 | FACS Data |
| 靶点 | Canine_PDL1 |
| uniprot-id | NP_001278901.1 |
| 用途 | For research use only. |
Figure 1. Flow cytometry analysis of Canine PDL1 overexpression using Canine_PDL1 293T Cell Line (Cat. No. CEL100114) and Canine PD-L1 Protein, hFc Tag(Cat. No. PME-D100009)
