Potent, selective and non-competitive mGlu5 receptor antagonist. Acts at allosteric modulatory site (Kd values are 54 and 31 nM at rat and human mGlu5 receptors respectively). Shows inverse agonist properties on receptor basal activity (IC50 value = 84 nM). Displays analgesic, anxiolytic and antidepressant effects. Orally active.
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