Language
- Adaptable: Suited for any injection route to target any organ 适应性:适用于任何注射路径，针对任何器官
- Safe: Maintain healthy animals and organs 安全:维护健康的动物和器官
- Time-saving: Ready-to-use reagent with an easy protocol 节省时间:易于使用的试剂
- Tailored: Customized protocols from in vivo delivery experts 量身定制:来自体内给药专家的定制方案
Overview（概述）
Specifications（规范）
Reagent
试剂in vivo -jetRNA®+ transfection reagent
Molecule delivered
转染核酸mRNA
Applications
应用Vaccination / immunization
Cancer therapy
in vivo functional studies (Gene expression, CRISPR genome editing)
疫苗 / 免疫研究
肿瘤治疗
体内功能研究(基因表达，CRISPR基因编辑)Targeted organs
靶向器官All organs (depending on the injection route)
所有器官(参考注射途径)Injection routes
注射途径Various administration routes (systemic or local)
多种注射途径（全身及局部）Number of injections in mice
试剂用量1 mL is sufficient to perform at least 50 intravenous injections or 100 intramuscular injections
1 mL足够在小鼠身上做50次静脉注射或者100次肌肉注射Storage
储存条件5 °C ± 3°C, stable for at least one year when stored appropriately
5 °C ± 3°CProvided with
配套提供mRNA buffer
mRNA 缓冲液
Summary（总结）in vivo transfection reagents are the most powerful alternative to viral vectors for nucleic acid delivery. They are easy to use, cost-effective and considered as safe and efficient vehicles for RNA delivery. mRNA transfection is rapidly emerging as a promising method for nucleic acid-based therapy and offers an attractive substitute to plasmid DNA. Non-viral mRNA delivery methods have already proven their efficiency in vaccination through antigen presenting cells modification and in anti-cancer therapy by directly targeting malignant cells. The intrinsic advantage of mRNA-based immunotherapy relies on the self-adjuvant activity of mRNA and the fact that small amounts of encoded antigen are sufficient to obtain robust immune response.
in vivo-jetRNA® is a transfection reagent specifically developed to deliver mRNA in vivo. This reagent can be used to target multiple organs, by using systemic or local injection routes, in various animal models. mRNA delivery using in vivo-jetRNA® is user-friendly, with a simple 2-step protocol and can be used for vaccination purposes, anti-cancer studies, genome editing using CRISPR/Cas9 method or protein replacement.
在体内转染试剂是最强大的替代病毒载体的核酸传递。它们易于使用，具有成本效益，被认为是安全有效的RNA传递载体。mRNA转染是一种很有前途的核酸治疗方法，是质粒DNA的一种很有吸引力的替代品。非病毒mRNA传递方法已经证明了它们通过抗原提呈细胞修饰接种疫苗和直接靶向恶性细胞的抗癌治疗的有效性。基于mRNA的免疫治疗的内在优势依赖于mRNA的自辅助活性，以及少量编码抗原就足以获得强大的免疫应答。
jetrna®是一种专门用于在体内传递mRNA的转染试剂。该试剂可用于靶向多个器官，通过使用全身或局部注射途径，在各种动物模型。在体内使用的mRNA传递- jetrna®是用户友好的，具有简单的2步协议，可用于疫苗接种目的，抗癌研究，使用CRISPR/Cas9方法进行基因组编辑或蛋白质替换。Ordering information（订购信息）
Reference Number Volume of in vivo-jetRNA® Volume of mRNA Buffer 101000122 in vivo -jetRNA®+ 1mL 1 mL delivery reagent + 60 mL mRNA Buffer
