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VitroGel® MMP HIGH CONCENTRATI

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江苏乐赛生物科技有限公司
13501696667 00000000
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  • Brand  VITROGEL
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Last Updated 2025-08-12 15:44

VitroGel® MMP HIGH CONCENTRATI

VITROGEL无动物源功能性凝胶准确模仿自然的细胞外基质(ECM)环境,生物功能性好,操作简便,为新药研发、组织工程、细胞治疗和个性化医疗提供了强大的3D细胞培养平台和注射给药系统。

无动物源功能性凝胶是3D细胞培养应用于临床研究的关键因素。VitroGel能高通量从细胞或患者来源的细胞建立3D器官模型。使用vitrogel作为注射给药系统,可以在细胞治疗中更好地保留细胞活性。这项突破性的技术使从3D水凝胶中回收细胞比以 往更加容易。


 

VitroGel® MMP HIGH CONCENTRATION修饰了金属蛋白酶,可被多种MMPs降解(MMP1、MMP2、MMP3、MMP9和MMP13),并支持不同的生物活动如细胞增殖、迁移、分化、血管生成、凋亡等。

MMP2酶降解VitroGel® MMP

 

A) 在凝胶顶部添加MMP2(1µg/mL)前不稀释,在37℃、5%二氧化碳、以40rpm摇床条件下中孵育24小时。六天后凝胶中间部分出现降解。

B) 1:3稀释Vitrogel并添加MMP2,6小时后Vitrogel几乎被完全降解。

C) 流变学数据显示在加入MMP2后,B组Vitrogel的弹性模量随时间的推移而迅速下降。

D) 胶质母细胞瘤细胞(SNB 75)在VitroGel® MMP中3D培养。

 

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