BCPAP细胞系

Bcpap/Bcpap细胞系/Bcpap细胞株/Bcpap人甲状腺癌乳头状细胞Cell line name B-CPAP

Synonyms BC-PAP; BCPAP

Accession CVCL_0153

Resource Identification Initiative To cite this cell line use: B-CPAP (RRID:CVCL_0153)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: TCGA-110-CL cell line panel.

Population: Caucasian.

Doubling time: ~30 hours (DSMZ=ACC-273).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Caution: Originally classified a thyroid gland papillary carcinoma (PTC) but is now considered to be a poorly differentiated thyroid gland carcinoma (PDTC) (PubMed=23162534).

Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.

PubMed=1297527

Paulin C., Fabien N., Fusco A., Pages M.-P., Patricot M.-C., Bornet H., Dubois P.-M.

Description of a cell line established from a human thyroid papillary carcinoma and synthesizing human chorionic gonadotropin hormone.

C. R. Acad. Sci. III, Sci. Vie 315:493-498(1992)

PubMed=8156527; DOI=10.1002/1097-0142(19940415)73:8<2206::AID-CNCR2820730828>3.0.CO;2-M

Fabien N., Fusco A., Santoro M.M., Barbier Y., Dubois P.-M., Paulin C.

Description of a human papillary thyroid carcinoma cell line Morphologic study and expression of tumoral markers.

Cancer 73:2206-2212(1994)

PubMed=11439348; DOI=10.1038/sj.onc.1204531

Frasca F., Vigneri P., Vella V., Vigneri R., Wang J.Y.-J.

Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.

Oncogene 20:3845-3856(2001)

PubMed=14522906

Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.

p73 tumor-suppressor activity is impaired in human thyroid cancer.

Cancer Res. 63:5829-5837(2003)

PubMed=15172756; DOI=10.1016/j.cancergencyto.2003.09.023

Dettori T., Frau D.V., Garcia J.L., Pierantoni G.M., Lee C., Hernandez-Rivas J.M., Fusco A., Morton C.C., Vanni R.

Comprehensive conventional and molecular cytogenetic characterization of B-CPAP, a human papillary thyroid carcinoma-derived cell line.

Cancer Genet. Cytogenet. 151:171-177(2004)

PubMed=17725429; DOI=10.1089/thy.2007.0097

Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.

Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.

Thyroid 17:707-715(2007)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026

van Staveren W.C.G., Weiss-Solis D.Y., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.-E., Detours V., Maenhaut C.

Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.

Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569

Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C., Haugen B.R.

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892

Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.

Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.

BMC Cancer 8:371.1-371.11(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662

Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22087789; DOI=10.1186/1755-8166-4-26; PMCID=PMC3248874

Maric I., Viaggi S., Caria P., Frau D.V., Degan P., Vanni R.

Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations.

Mol. Cytogenet. 4:26.1-26.8(2011)