Medicine Platform

IL-4Rα/ CD124 (C-Fc), Human, R

  • 收藏 0

Price

  • $3566.67元/

武汉益普生物科技有限公司
13657268723 00000000
  • 发货地  Armenia
  • 品 牌  Procell
本公司精品橱窗推荐
  • 资本:未填写
  • 类型:企业单位
  • 主营:生物试剂,试验室仪器,技术服务
  • 地区:Armenia
本页信息为武汉益普生物科技有限公司为您提供的“IL-4Rα/ CD124 (C-Fc), Human, R”产品信息,如您想了解更多关于“IL-4Rα/ CD124 (C-Fc), Human, R”价格、型号、厂家,请联系厂家,或给厂家留言。
询价 暂无
发货 Armenia
品牌 Procell
过期 长期有效
更新 2025-08-12 16:28

IL-4Rα/ CD124 (C-Fc), Human, R

产品信息

别名Interleukin-4 Receptor subunit alpha; IL-4 Receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding Protein; IL4-BP; IL4R; IL4RA
物种Human
表达宿主Human Cells
序列信息Met26-Gln231
检索号P24394
分子量50.2 kDa
表观分子量60-70 kDa
标签C-Fc
生物活性Measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells.The ED50 for this effect is 5-20 ng/ml.

 

产品特性

纯度>95% as determined by reducing SDS-PAGE.
内毒素<1.0 EU per µg as determined by LAL test.
保存Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输Ambient temperature or ice pack.
制剂Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

背景介绍

Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glyco Protein in the class I Cytokine Receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a Cytokine binding region and one fibronectin type III domain, a 24 aa transmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 Motif and one ITIM Motif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra, generated by alternate splicing or proteolysis, retain Ligand binding properties and inhibit IL-4 bioactivity. IL4-Ra is a component of two distinct Receptor complexes and shows species selectivity between human and mouse. It can associate with the common gamma chain (γc) to form the IL-4 responsive type I Receptor in which γc increases the affinity for IL-4 and enables signaling. It can alternatively associate with IL13-Ra1 to form the type II Receptor which is responsive to both IL-4 and IL-13. The use of shared Receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other Cytokines that utilize γc.

公司名 武汉益普生物科技有限公司 经营模式未填写
注册资本未填写 公司注册时间2017年
公司所在地Armenia 企业类型企业单位 ()
主营行业
主营产品或服务生物试剂,试验室仪器,技术服务
联系方式
Medicine Platform
 
Disclaimer:
当前页为价格信息展示,该页所展示的批发价格、报价等相关信息均有企业自行提供,价格真实性、准确性、合法性由店铺所有企业完全负责。Medicine Platform对此不承担任何保证责任。
Reminder:
建议您通过拨打厂家联系方式确认最终价格,并索要样品确认产品质量。如报价过低,可能为虚假信息,请确认报价真实性,谨防上当受骗。