Language
| 基本信息 | |
| CAS | No.57-71-6 |
| 中文名称 | 2,3-丁烷二酮一肟 |
| 英文名称 | 2,3-Butanedione monoxime |
| 别名 | 2，3-Butanedione-2-monoxime;Diacetyl monoxime |
| 分子式 | C4H7NO2 |
| 分子量 | 101.1 |
| 溶解性 | Soluble in DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00002116 |
| SMILES | C/C(=NO)/C(=O)C |
| InChIKey | FSEUPUDHEBLWJY-HWKANZROSA-N |
| InChI | InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H，1-2H3/b5-3+ |
| PubChem CID | 6409633 |
| 靶点 | Myosin |
| 通路 | Cytoskeleton |
| 背景说明 | 2,3-Butanedione monoxime是一种肌球蛋白 ATP 酶 (myosin ATPase) 抑制剂。2,3-Butanedione monoxime也是一种骨骼肌肌球蛋白 II（myosin-II）的非竞争性抑制剂。2,3-Butanedione monoxime诱导肌质网 Ca2+ 释放。 |
| 生物活性 | Biacetyl monoxime (Diacetyl monoxime)， a myosin ATPase inhibitor， is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1-3]. |
| In Vitro | Biacetyl monoxime(50 mM，2 and 4 h)disrupts the localization of the Golgi apparatus，but not that of the endoplasmic reticulum[1].Biacetyl monoxime(0-30 mM)induces SR Ca2+ release(no efflux inhibitors)in a concentration-dependent manner，with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase，which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction[2].Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms，myosin-V，or myosin-VI[3]. |
| 数据来源文献 | [1]. Kohsuke Hashimoto， et al. The myosin ATPase inhibitor， 2，3-butanedione 2-monoxime， prevents protein secretion by the basidiomycete Coprinopsis cinerea. Biotechnol Lett. 2011 Apr;33(4):769-75. [2]. R M Phillips， et al. 2，3-Butanedione 2-monoxime (BDM) induces calcium release from canine cardiac sarcoplasmic reticulum. Biochem Biophys Res Commun. 1996 Dec 4;229(1):154-7. [3]. Ostap EM. 2，3-Butanedione monoxime (BDM) as a myosin inhibitor. J Muscle Res Cell Motil. 2002;23(4):305-8 |
| 单位 | 瓶 |
