| Cas No.: 95058-81-4 | 分子量 : 263.20 |
| 分子式 : C9H11F2N3O4 | 纯度 : >99 % |
| 同义名 : LY 188011; NSC 613327; Zefei; LY188011; LY-188011 | |
| 化学名 : 3-Pyridinecarboxamide, 4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | |
| 外观 : 白色至浅黄色固体 | |
| 溶解 : 溶于 DMSO (up to 100 mg/ml) | |
| 保存： 2 年 -20 ℃ 固体 | |
| 储存液 (1 ml DMSO 体系 ) | 1 mM | 5 mM | 10 mM |
| 质量 (mg) | 0.2632 | 1.3160 | 2.6320 |
使用浓度 ( 仅作参考 )
Gemcitabine 的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
参考文献
[1] Plunkett W,et al. Preclinical characteristics of gemcitabine. Anticancer Drugs. 6:7-13(1995).
[2]Holcomb BK, et al. Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. J Gastrointest Surg. 16(7):1333-40(2012).
[3]Chen SH, et al. Gemcitabine-induced pancreatic cancer cell death is associated with MST1/cyclophilin D mitochondrial complexation. Biochimie. 103:71-9(2014).
[4]Matthews DJ, et al. Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo. Cell Cycle. 6(1):104-10(2007).
[5] Ramachandran C, et al. Potentiation of gemcitabine by Turmeric Force in pancreatic cancer cell lines.Oncol Rep. 23(6):1529-35(2010).
