细胞组织工程三维培养生物反应器

• 三维细胞牵张应力加载刺激：对生长在三维状态下的细胞进行静态的或者周期性的拉应力刺激
  通过Flexcell应力加载系统和弧矩形加载平台对生长在三维环境下的细胞进行单轴向
  或者双轴向的静态或者周期性的应力加载刺激培养
• 三维细胞培养：使用三维组织培养模具和三维细胞培养板可以进行三维细胞培养在凝胶支架里全自动三维培养
  三维组织培养模具和三维细胞培养板类型丰富：
  1)三维组织培养模具有三维线形培养加载基站模具和三维梯形培养加载基站模具
  2)具有氨基酸包被表面、胶原（I型或IV）包被表面、弹性蛋白包被表面、ProNectin（RGD）包被表面、层粘连蛋白（YIGSR）包被表面的三维培养板。
  科研者根据自己的细胞，有针对性的选择适合包被表面三维培养板
  3)具有可牵拉双轴向和单轴向拉力刺激加载三维组织培养板。
• 大体积三维生物人工组织培养构建：可构建长度达35mm的生物人工组织
• 动力模拟实验:可建立特制的各种模拟实验：心率模拟实验、步行模拟实验、跑动模拟实验和其他动力模拟实验
• 本系统技术先进性：
  1）安全快速的扩增细胞
  2）在细胞特异性基质(圆盘形陶瓷载体培养片) 中进行三维的细胞高密度培养
  3）扩增并获得可用于治疗的有活性的原代细胞
  4）在控制分化状态的条件下扩增干细胞
  5）向植入的一代细胞提供植入支架
  6）长期培养分泌细胞
  7）高效生产重组蛋白和疫苗
  8）生产优质的糖蛋白
  9）三维培养与机械力刺激有机结合
  10）三维凝胶压实自动测量与面积自动计算
• 可用于多个领域，如研究、生物制药加工；也可为细胞和组织培养工作提供解决方案：
  1）可用于干细胞和胚体扩增及定向分化
  2）可用于细胞和组织治疗的细胞制备
  3）可用于克隆细胞，为器官移植做准备（例如hip stem, heart valve, graft）
  4）可用于制备天然的生物制品（例如糖蛋白、病毒、病毒样颗粒）
• 观察细胞应力下实时反映：使用Flexcell独有的Flexcell StageFlexer Jr.显微附属设备，可在加力刺激的同时实时观察细胞在三维状态下牵拉刺激的反应
• 多种基质蛋白包被的尼龙网锚可以加强细胞与网锚的结合

TISSUE TRAIN®AND 3D CULTURE SYSTEM 应用文献

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