HoloMonitor M4 激光全息活细胞成像及分析系统

激光全息技术提供无标记，非侵入实时细胞成像分析，提供完整的细胞形态学参数及运动性分析，可广泛应用于细胞增殖，分化，计数，迁移，凋亡等方面研究。针对细胞迁移研究，激光全息可以给出每个细胞的迁移数据（速度、轨迹、位移等）以及在运动过程中细胞的3D形态变化数据。
瑞典Phiab公司是领先的激光数字全息细胞分析仪供应商，领先的全息技术并结合了流式细胞分析仪。全新升级高通量细胞检测，满足实验需求中6-96孔板同时检测。简单，快捷地解决您的细胞检测问题。
应用领域：
细胞迁移追踪 肿瘤生物学 细胞毒理研究 细胞周期
细胞增殖分化 细胞活力 药理药效研究 干细胞生物学
纳米材料生物学效应 神经毒理学 巨噬细胞极化 基因治疗
最全面的细胞形态学定量分许



细胞迁移运动分析



划痕实验



细胞增殖分化研究



细胞增殖计数



细胞周期研究


细胞凋亡与坏死研究


细胞坏死 细胞凋亡
全新M4升级版配备电动载物台可以移动拍摄。用户自行设定需要同时检测的处理孔及自定义选取拍摄的位置、拍摄总时间、拍摄间隔时间。软件会自己计算出最终的拍摄图片数量，按设定程序逐点连续拍摄，拍摄过程中自动聚焦，拍摄结束后，可以以视频、数据、图片等多种方式输出。

参考文献：

1. Yuan G, Wang Z, Qiang H, et al. Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin[J]. Nature Communications, 2017, 8:14483.
2. Mo W C, Zhang Z J, Wang D L, et al. Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells.[J]. Scientific Reports, 2016, 6:22624.
3. Interfacing antibody-based microarrays and digital holography enables label-free detection for loss of cell volume Future Sci. OA (2015) 10.4155/FSO.14.2 © Z El-Schich et al. FSO1
4. Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and miRNA-34a Co-Delivery Triggered by Dual Stimuli in Tumor Tissue (2016) Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
5. From immobilized cells to motile cells on a bed-of-nails: effects of vertical nanowire array density on cell behaviour Article in Scientific Reports · December (2015)
6. Pseudomonas aeruginosal asI/rhlI quorum sensing genes promote phagocytosis and aquapor in 9 redistribution to the leading and trailing regions in macrophages Angelika Holm, Thommie Karlsson and Elena Vikström *Frontiers in Microbiology Received: 05 June (2015)
7. Holographic microscopy video showing asymmetrical cell division of JIMT-1 cells B. Janicke The CELL — an imaging library (2012) Available from: http://www.cellimagelibrary.org/images/43451
8. Holographic time-lapse video showing live human prostate cells (DU 145) undergoing apoptosis, induced by etoposide B. Janicke The CELL — an imaging library (2012) Available from: http://www.cellimagelibrary.org/images/43705
9. Prevention and treatment of colon cancer by peroral administration of HAMLET M. Puthia, P. Storm, A. Nadeem, S. Hsiung, C. Svanborg Gut, 0:1-12, doi:10.1136/gutjnl-2012-303715 (2013)
10. Low Resolution Solution Structure of HAMLET and the Importance of Its Alpha-Domains in Tumoricidal Activity J. Ho CS, A. Rydstrom, M. S. S. Manimekalai, C. Svanborg and G. Grüber PLoS ONE 7(12):e53051 (2012)
11. Dermatan Sulfate is involved in the tumorigenic properties of esophagus squamos cell carcinom M. A. Thelin, K. J. Svensson, X. Shi et al. Cancer Res72:1943-1952 (2012)
12. HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment Trulsson et al.PLoS ONE 6(3):e17179 (2011)