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产品详细描述
产品详细描述
详细配制内容及参数资料
1.1 特点
l可以做更准确的药代动力学和毒物学的研究
l更清楚准确的反应了体内血脑屏障的特性
l模拟重要的内皮细胞与星形胶质细胞之间的作用
l用电力方法检测了血脑屏障的完整性
l可以用真实的细胞做实验
l比现存的静态模型更能形成紧密的连接
l降低药物研发的成本
1.2 配置及参数资料
TEER检测系统CARTRIDGE底板
4个DIV-BBB盒子检测软件电缆线
DIV-BBB?管腔
| 特性 | 优点 |
| 可控制腔内/非腔体积比 体型小，仅7cm长 电极与管腔一体化 成本低 | 与体内体积比相符 减少了试验所需细胞数目 TEER检测系统操作简单 一次性使用，不能重复使用 |
经毛细管孔径：0.2um
中空纤维数量：19
腔内总体积：0.0123in3= 0.202cm3
腔内表面积：2.09 in3= 13.5cm2
腔外体积：0.070 in3= 1.15cm3
腔外中空纤维总面积：3.50 in3= 22.6cm2
TEER检测系统
TEER检测系统为研发人员提供了一个快速、简便地评估血脑屏障完整性方法，此外，电阻抗值（＞1000 Ω-cm2）也非常接近体内数值。TEER检测系统同时配带了所需检测软件、电线和衬板，可供4个DIV-BBB管腔同时使用。其中检测软件可以自定义设置泵的流速、频率、波形等参数。其它特性及优点见下表：
| 特性 | 优点 |
| 多频率下检测电阻抗 | 描述电极的电阻和电容 |
| 低电压，Max=60毫伏 | 限制对屏障的潜在破坏作用 |
| 自动检测多个管腔 | 可同时连接4个盒子 |
| 检测软件可自定义设置泵的流速、频率、波形等参数 | 检测电阻抗，记录数据 |
| USB连接 | 台式或者便携式电脑均可连接 |
脉动泵
脉搏率和作用周期完全模拟体内血液动力学设计，贴近体内环境，试验准确，脉搏率可设置在30-120/分范围内。其特性和优点见下：
| 特性 | 优点 |
| 4个管腔的流速和泵的速度可分别控制， | 允许4个独立试验 |
| 外部24电压墙与电源连接 | 减少培养箱中高温 |
| 接受来自TEER检测系统的指定程序 | 不需要额外的USB接口 |
电脑配置最低要求
?IBM兼容电脑，400MHz或者更快
?Window 2000或者更高系统
?128MB存储器（推荐256MB）
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About Flocel
Every year millions of dollars are spent by pharmaceutical companies to develop and test drugs using in vitro models of the Blood-Brain Barrier (BBB). Many of these cases end up not working in vivo.CleveMedhas licensed technology fromThe Cleveland Clinic Foundation and formed Flocel Inc, to manufacture a practical in vitro model that more accurately reflects the BBB characteristics. Flocel's dynamic in vitro blood-brain barrier (DIV-BBB) technology helps researchers in the United States and Europe conduct in vitro studies.
Flocel also offers atesting service for BBB permeability compounds. To learn more about our testing services, clickhere.
Introduction to the Blood-Brain Barrier
TThe blood-brain barrier (BBB) explains why certain substances circulating in the blood are able to get into the brain and others do not. The BBB is formed by brain capillaries that look like simple tubes of endothelial cells. Experimental and clinical evidence suggests that the BBB maintains the chemical environment for neuronal function and protects the brain from harmful substances. The blood-brain barrier is therefore crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases, and issues related to bio-defense. We have developed a practical in vitro model that accurately reflects BBB characteristics.
Benefits of Flocel’s in vitro BBB Model
In contrast to other available models of the blood-brain barrier, Flocel's Dynamic In vitro Blood-Brain Barrier (DIV-BBB) respects the anatomical aspects of the in situ endothelial cell-astrocyte interactions and replicates the physiological levels of shear stress to which in situ endothelial cells are exposed. The DIV-BBB allows formation of physiological transendothelial resistance, and formation of gap junctions that can be easily visualized at the electron microscope or determined experimentally with the use of tracers.
