Language
饲养层细胞 干细胞 骨髓移植 肿瘤学 免疫学 DNA损伤相关 信号转导 基因组学 放射生物学 小动物辐照 药物研发 等生物医学领域Welcome to RAD Source Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info； REASONS WHY THE RAD SOURCE RS 2000 X-RAY IRRADIATOR IS THE SYSTEM OF CHOICE FOR YOUR RESEARCH AND BIOLOGICAL IRRADIATION REQUIREMENTS The RS 2000 is a research & biological irradiator that features the following advantages: The RS 2000 is self-contained and requires no external cooling system NO Nuclear Site license or secure/shielded room is needed The RS 2000 is ideal for small animal research when using our patented RAD + reflective cage enclosure. This unique and patented feature provides for a dose rate within the cage of 1.2 Gy/min (120 rads/min or the same as gamma irradiator) and the dose distribution is better than 94% across the entire field (much better than a gamma irradiator). The RAD+ is designed to hold one standard Allentown filtered rearing cage. (Three of which are supplies with the system.) This feature improves animal husbandry by allowing transport and irradiation of the animals inside a filtered environment mitigating cross-contamination issues. Because the animals are irradiated in their cage, multiple mice can be irradiated during one cycle. IF itis important for you to have reproducible results that equate to theirradiation standard of Cesium - the only choice is the RS 2000 with .3mm of Copper filter irradiating at 160 kV AT 25 mA (NEW 225 kV available). The RS 2000 is ideal for targeted tumor irradiation using our spot beam collimator or custom animal shielding and offers variable dose rates to the target. For Cells and other research the RS 2000 has dose rates of >5 Gy/min (500 rads/min.) filtered and up to >17 Gy/min unfiltered. This is the only system available that allows for 160 kV operation @ 25 mA (not “AND or OR” but AT 25 mA) “Plug and Play” installation: Installation, dose-mapping & in-service in one day. Mounted on wheels Footprint 33” X 42” (82.8 cm X 106.7 cm) and weighs 1250 lbs (567 kg). Simple touch screen operators’ panel for ease of use and operation. Please review the information on our website: Rad Source is the recognized expert in the field of x-ray irradiation. We developed the only US-FDA approved blood irradiator for replacing Cs irradiators and are the leaders in high dose, high volume irradiation systems worldwide The RS 2000 should be the choice for your next professional quality biological and research irradiator Features · “Plug and Play” Installation · Unit is mounted on caster wheels for easy movement · Self-contained cooling · Easy access to built-in calibration port · Specialized filtration eliminates lower energy X-rays · Optimal for split-dose delivery · Easy to use touch screen operation · CE Marked & Compliant · Renewable Ionizing Radiation · No NRC License Required · No shielded or secure room required · No disposal costs
部分科研机构文献
RAD SOURCE RS2000系列产品得到了广泛应用，文献发表在以下期刊：Cancer Res.、BLOOD、PANS、CELL、Stem Cell Biology、JEM、Nature、The Journal of Immunology、Hematology and Stem Cells、Stem Cells、PLoS Biology、Liver、I Int. J. Biol. Sci.、THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS、MOLECULAR AND CELLULAR BIOLOGY、Experimental Hematology等。 1、DNA damage checkpoint control in cells exposed to ionizing radiation NATURE George Iliakis*,1, Ya Wang2, Jun Guan2 and Huichen Wang2 1Institute of Medical Radiation Biology, University of Essen Medical School, Hufelanstrasse 55, 45122 Essen, Germany; 2Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA 2、Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status CELL Centre de recherche CHU Ste-Justine, Montre´ al, QC, Canada； 2Lawrence Berkeley National Laboratory, Berkeley, CA, USA 3Buck Institute for Age Research, Novato, CA, USA；4Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, CO, USA 3、Nuclear Localization of p38 MAPK in Response to DNA Damage I Int. J. Biol. Sci. 2009, 5 C. David Wood1, Tina M. Thornton1, Guadalupe Sabio2, Roger A. Davis2, 1. Department of Medicine/Immunobiology Program, University of Vermont, Burlington, VT 05405. USA. 2. Program in Molecular Medicine, University of Massachusetts, Worcester, MA 01605.Correspondence to: Mercedes Rincon Received: 2009.04.30; Accepted: 2009.06.10; Published: 2009.06.16 4、Passive and Active Mechanisms Trap Activated CD8+ T Cells in the ... The Journal of Immunology Six- to 8-wk-old mice were irradiated with 1000 rad (10 Gy) as a single dose from an RS2000 x-ray irradiator (Rad Source; Rad Source Technologies, Coral Springs, FL) and used as recipients. Mature T cells were depleted from donor bone ... 5、Expression of common chromosomal fragile site genes, VVWOX/FRA 16D .. MOLECULAR CARCINOGENESIS fluency were irradiated in RS2000 X-ray Irradiator. (Rad Source Technologies, Inc., Boca Raton, FL). Control cells were sham-irradiated in both the UV-. C and ionizing radiation (IR) experiments. For BPDE. treatment,8t-dihydroxy-9 ... doLwiley.com 6、Complete differentiation of CD8+ T cells activated locally within ... JEM 6 8-wk-old recipient mice were irradiated with a dose of 10 Gy (1000 rad) using an RS2000 X-ray irradiator (RadSource Technologies). Depletion of mature T lymphocytes from donor bone marrow cells was achieved by incubation with anti-CD4 ... 7、An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells BLOOD Monica L. Guzman,1 Randall M. Rossi,1 Sundar Neelakantan,2 Xiaojie Li,1 Cheryl A. 8、Ku86 Modulates DNA Topoisomerase I–Mediated Radiosensitization, but not Cytotoxicity, in Mammalian Cells Cancer Res 2005 Shyh-Jen Shih, Tara Erbele, and Allan Y. Chen Department of Radiation Oncology, University of California Davis Medical Center, Sacramento,California 9、Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal Inflammation PANS Simona Zarini1, Miguel A. Gijo´ n1, Aaron E. Ransome, Robert C. Murphy2 Department of Pharmacology, University of Colorado Denver, Mail Stop 8303, 12801 East 17th Avenue, Aurora Communicated by K. Frank Austen, Brigham and Women’s Hospital, Boston, MA, April 7, 2009 (received for review February 23, 2009) 10、Irradiation Selects for p53-Deficient Hematopoietic Progenitors PLoS Biology Andriy Marusyk1,2¤, Christopher C. Porter1,3, Vadym Zaberezhnyy1 DeGregori1,2,3,4* Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America, 2 Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America 11、Kupffer cell heterogeneity: functional properties of bone marrow–derived and sessile hepatic macrophages BLOOD Ingo Klein, 1,2 Judith C. Cornejo,3 Noelle K. Polakos,2 Beena John,2 Sherry A. 1David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, NY; Received February 11, 2007; Accepted July 25, 2007. 12、Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors Cancer Res 2009 Andriy Marusyk,1,2 Matias Casa′s-Selves,1,2 Curtis J. Henry,1,4 Vadym Zaberezhnyy,1 Jelena Klawitter,5 Uwe Christians,5 and James DeGregori1,2,3,4 1Department of Biochemistry and Molecular Genetics, 2Program in Molecular Biology, 3Department of Pediatrics, 4Integrated Department of Immunology; and 5Department of Anesthesiology, University of Colorado Denver School of Medicine, Aurora, Colorado 13、Progression of Pancreatic Adenocarcinoma Is Significantly Impeded with a Combination of Vaccine and COX-2 Inhibition1 The Journal of Immunology Pinku Mukherjee,2* Gargi D. Basu,† Teresa L. Tinder,* Durai B. Subramani,* Judy M. Bradley,* Million Arefayene,‡ Todd Skaar,‡ and Giovanni De Petris§
